![]() Correlations between hydrogels structural properties was also investigated. Hydrogel structure was confirmed by FTIR, XRD, TGA, DSC, and SEM showed a porous structure. A total of 61 compounds were identified in the Pueraria lobatae-SD using UHPLC-Q-TOF-MS analysis. In the current study, chitosan/xanthan gum-based (hydroxypropyl methylcellulose- co-2-acrylamido-2-methylpropane sulfonic acid) hydrogels for the controlled release of Pueraria lobata-solid dispersion (SD) were successfully prepared and characterized. The therapeutic efficacy of these agents is hampered by their poor pharmacokinetic profiles (rapid systemic clearance, low oral bioavailability, short half-life) and physicochemical properties (such as poor aqueous solubility and stability). Some of its active components include the flavonoids puerarin, daidzin, daidzein, and genistin. Pueraria lobatae (Willd) Ohwi is a traditional Chinese medicine used to treat alcohol intoxication, diabetes, cerebrovascular and cardiovascular diseases.
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